Multiple organ involvement by alpha-synuclein pathology in Lewy body disorders.
Identifieur interne : 000509 ( Main/Exploration ); précédent : 000508; suivant : 000510Multiple organ involvement by alpha-synuclein pathology in Lewy body disorders.
Auteurs : Ellen Gelpi [Espagne] ; Judith Navarro-Otano ; Eduardo Tolosa ; Carles Gaig ; Yaroslau Compta ; María Jesús Rey ; Maria José Martí ; Isabel Hernández ; Francesc Valldeoriola ; Ramon Re É ; Teresa RibaltaSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2014.
English descriptors
- KwdEn :
- Adrenal Glands (metabolism), Adrenal Glands (pathology), Aged, Aged, 80 and over, Autonomic Nervous System (metabolism), Autonomic Nervous System (pathology), Central Nervous System (metabolism), Central Nervous System (pathology), Female, Gastrointestinal Tract (metabolism), Gastrointestinal Tract (pathology), Humans, Lewy Body Disease (metabolism), Lewy Body Disease (pathology), Male, Myocardium (metabolism), Myocardium (pathology), Retrospective Studies, Urogenital System (metabolism), Urogenital System (pathology), alpha-Synuclein (metabolism).
- MESH :
- chemical , metabolism : alpha-Synuclein.
- metabolism : Adrenal Glands, Autonomic Nervous System, Central Nervous System, Gastrointestinal Tract, Lewy Body Disease, Myocardium, Urogenital System.
- pathology : Adrenal Glands, Autonomic Nervous System, Central Nervous System, Gastrointestinal Tract, Lewy Body Disease, Myocardium, Urogenital System.
- Aged, Aged, 80 and over, Female, Humans, Male, Retrospective Studies.
Abstract
Lewy body (LB) diseases are characterized by alpha-synuclein (AS) aggregates in the central nervous system (CNS). Involvement of the peripheral autonomic nervous system (pANS) is increasingly recognized, although less studied. The aim of this study was to systematically analyze the distribution and severity of AS pathology in the CNS and pANS. Detailed postmortem histopathological study of brain and peripheral tissues from 28 brain bank donors (10 with Parkinson's disease [PD], 5 with dementia with LB [DLB], and 13 with non-LB diseases including atypical parkinsonism and non-LB dementia). AS aggregates were found in the pANS of all 15 LB disease cases (PD, DLB) in stellate and sympathetic ganglia (100%), vagus nerve (86.7%), gastrointestinal tract (86.7%), adrenal gland and/or surrounding fat (53.3%), heart (100%), and genitourinary tract (13.3%), as well as in 1 case of incidental Lewy body disease (iLBD). A craniocaudal gradient of AS burden in sympathetic chain and gastrointestinal tract was observed. DLB cases showed higher amounts of CNS AS aggregates than PD cases, but this was not the case in the pANS. No pANS AS aggregates were detected in Alzheimer's disease (AD) cases with or without CNS AS aggregates. All pathologically confirmed LB disease cases including 1 case of iLBD had AS aggregates in the pANS with a craniocaudal gradient of pathology burden in sympathetic chain and gastrointestinal tract. AS was not detected in the pANS of any AD case. These findings may help in the search of peripheral AS aggregates in vivo for the early diagnosis of PD.
DOI: 10.1002/mds.25776
PubMed: 24395122
Affiliations:
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Le document en format XML
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Navarro-Otano</name></author><author><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name></author><author><name sortKey="Gaig, Carles" sort="Gaig, Carles" uniqKey="Gaig C" first="Carles" last="Gaig">Carles Gaig</name></author><author><name sortKey="Compta, Yaroslau" sort="Compta, Yaroslau" uniqKey="Compta Y" first="Yaroslau" last="Compta">Yaroslau Compta</name></author><author><name sortKey="Rey, Maria Jesus" sort="Rey, Maria Jesus" uniqKey="Rey M" first="María Jesús" last="Rey">María Jesús Rey</name></author><author><name sortKey="Marti, Maria Jose" sort="Marti, Maria Jose" uniqKey="Marti M" first="Maria José" last="Martí">Maria José Martí</name></author><author><name sortKey="Hernandez, Isabel" sort="Hernandez, Isabel" uniqKey="Hernandez I" first="Isabel" last="Hernández">Isabel Hernández</name></author><author><name sortKey="Valldeoriola, Francesc" sort="Valldeoriola, Francesc" uniqKey="Valldeoriola F" 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type="wicri:Area/Main/Exploration">000509</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Multiple organ involvement by alpha-synuclein pathology in Lewy body disorders.</title><author><name sortKey="Gelpi, Ellen" sort="Gelpi, Ellen" uniqKey="Gelpi E" first="Ellen" last="Gelpi">Ellen Gelpi</name><affiliation wicri:level="3"><nlm:affiliation>Neurological Tissue Bank of the Biobanc-Hospital Clinic-Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Neurological Tissue Bank of the Biobanc-Hospital Clinic-Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Navarro Otano, Judith" sort="Navarro Otano, Judith" uniqKey="Navarro Otano J" first="Judith" last="Navarro-Otano">Judith Navarro-Otano</name></author><author><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name></author><author><name sortKey="Gaig, Carles" sort="Gaig, Carles" uniqKey="Gaig C" first="Carles" last="Gaig">Carles Gaig</name></author><author><name sortKey="Compta, Yaroslau" sort="Compta, Yaroslau" uniqKey="Compta Y" first="Yaroslau" last="Compta">Yaroslau Compta</name></author><author><name sortKey="Rey, Maria Jesus" sort="Rey, Maria Jesus" uniqKey="Rey M" first="María Jesús" last="Rey">María Jesús Rey</name></author><author><name sortKey="Marti, Maria Jose" sort="Marti, Maria Jose" uniqKey="Marti M" first="Maria José" last="Martí">Maria José Martí</name></author><author><name sortKey="Hernandez, Isabel" sort="Hernandez, Isabel" uniqKey="Hernandez I" first="Isabel" last="Hernández">Isabel Hernández</name></author><author><name sortKey="Valldeoriola, Francesc" sort="Valldeoriola, Francesc" uniqKey="Valldeoriola F" first="Francesc" last="Valldeoriola">Francesc Valldeoriola</name></author><author><name sortKey="Re E, Ramon" sort="Re E, Ramon" uniqKey="Re E R" first="Ramon" last="Re É">Ramon Re É</name></author><author><name sortKey="Ribalta, Teresa" sort="Ribalta, Teresa" uniqKey="Ribalta T" first="Teresa" last="Ribalta">Teresa Ribalta</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adrenal Glands (metabolism)</term><term>Adrenal Glands (pathology)</term><term>Aged</term><term>Aged, 80 and over</term><term>Autonomic Nervous System (metabolism)</term><term>Autonomic Nervous System (pathology)</term><term>Central Nervous System (metabolism)</term><term>Central Nervous System (pathology)</term><term>Female</term><term>Gastrointestinal Tract (metabolism)</term><term>Gastrointestinal Tract (pathology)</term><term>Humans</term><term>Lewy Body Disease (metabolism)</term><term>Lewy Body Disease (pathology)</term><term>Male</term><term>Myocardium (metabolism)</term><term>Myocardium (pathology)</term><term>Retrospective Studies</term><term>Urogenital System (metabolism)</term><term>Urogenital System (pathology)</term><term>alpha-Synuclein (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>alpha-Synuclein</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Adrenal Glands</term><term>Autonomic Nervous System</term><term>Central Nervous System</term><term>Gastrointestinal Tract</term><term>Lewy Body Disease</term><term>Myocardium</term><term>Urogenital System</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Adrenal Glands</term><term>Autonomic Nervous System</term><term>Central Nervous System</term><term>Gastrointestinal Tract</term><term>Lewy Body Disease</term><term>Myocardium</term><term>Urogenital System</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Male</term><term>Retrospective Studies</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lewy body (LB) diseases are characterized by alpha-synuclein (AS) aggregates in the central nervous system (CNS). Involvement of the peripheral autonomic nervous system (pANS) is increasingly recognized, although less studied. The aim of this study was to systematically analyze the distribution and severity of AS pathology in the CNS and pANS. Detailed postmortem histopathological study of brain and peripheral tissues from 28 brain bank donors (10 with Parkinson's disease [PD], 5 with dementia with LB [DLB], and 13 with non-LB diseases including atypical parkinsonism and non-LB dementia). AS aggregates were found in the pANS of all 15 LB disease cases (PD, DLB) in stellate and sympathetic ganglia (100%), vagus nerve (86.7%), gastrointestinal tract (86.7%), adrenal gland and/or surrounding fat (53.3%), heart (100%), and genitourinary tract (13.3%), as well as in 1 case of incidental Lewy body disease (iLBD). A craniocaudal gradient of AS burden in sympathetic chain and gastrointestinal tract was observed. DLB cases showed higher amounts of CNS AS aggregates than PD cases, but this was not the case in the pANS. No pANS AS aggregates were detected in Alzheimer's disease (AD) cases with or without CNS AS aggregates. All pathologically confirmed LB disease cases including 1 case of iLBD had AS aggregates in the pANS with a craniocaudal gradient of pathology burden in sympathetic chain and gastrointestinal tract. AS was not detected in the pANS of any AD case. These findings may help in the search of peripheral AS aggregates in vivo for the early diagnosis of PD.</div></front></TEI><affiliations><list><country><li>Espagne</li></country><region><li>Catalogne</li></region><settlement><li>Barcelone</li></settlement></list><tree><noCountry><name sortKey="Compta, Yaroslau" sort="Compta, Yaroslau" uniqKey="Compta Y" first="Yaroslau" last="Compta">Yaroslau Compta</name><name sortKey="Gaig, Carles" sort="Gaig, Carles" uniqKey="Gaig C" first="Carles" last="Gaig">Carles Gaig</name><name sortKey="Hernandez, Isabel" sort="Hernandez, Isabel" uniqKey="Hernandez I" first="Isabel" last="Hernández">Isabel Hernández</name><name sortKey="Marti, Maria Jose" sort="Marti, Maria Jose" uniqKey="Marti M" first="Maria José" last="Martí">Maria José Martí</name><name sortKey="Navarro Otano, Judith" sort="Navarro Otano, Judith" uniqKey="Navarro Otano J" first="Judith" last="Navarro-Otano">Judith Navarro-Otano</name><name sortKey="Re E, Ramon" sort="Re E, Ramon" uniqKey="Re E R" first="Ramon" last="Re É">Ramon Re É</name><name sortKey="Rey, Maria Jesus" sort="Rey, Maria Jesus" uniqKey="Rey M" first="María Jesús" last="Rey">María Jesús Rey</name><name sortKey="Ribalta, Teresa" sort="Ribalta, Teresa" uniqKey="Ribalta T" first="Teresa" last="Ribalta">Teresa Ribalta</name><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name><name sortKey="Valldeoriola, Francesc" sort="Valldeoriola, Francesc" uniqKey="Valldeoriola F" first="Francesc" last="Valldeoriola">Francesc Valldeoriola</name></noCountry><country name="Espagne"><region name="Catalogne"><name sortKey="Gelpi, Ellen" sort="Gelpi, Ellen" uniqKey="Gelpi E" first="Ellen" last="Gelpi">Ellen Gelpi</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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